(of DNA) The N-glycosidic link between purine bases and deoxyribose in DNA has an appreciable rate of spontaneous cleavage in vivo, a lesion that must be enzymically repaired to ensure stability of the genetic information.

Dictionary of molecular biology. 2004.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Depurination — In molecular genetics, depurination is an alteration of DNA in which the purine base (adenine or guanine) is removed from the deoxyribose sugar by hydrolysis of the beta N glycosidic link between them. After depurination, an apurinic site is… …   Wikipedia

  • Dépurination et dépyrimidination — Lors de la dépurination (et de la dépyrimidination), le lien se rompt entre une base et le squelette du brin d ADN, ce qui libère la base et laisse une anomalie (un site vacant) appelé site AP. La dépurination est une altération de l ADN où se… …   Wikipédia en Français

  • depurination —    The process of partial DNA hydrolysis by acid at purine (adenine and guanine) sites, resulting in the cleavage of large DNA fragments into smaller pieces. This process improves Southern transfer …   Forensic science glossary

  • Mutagenesis — (pronounced /mjuːtəˈdʒɛnɪsɪs/) is a process by which the genetic information of an organism is changed in a stable manner, resulting in a mutation. It may occur spontaneously in nature, or as a result of exposure to mutagens. It can also be… …   Wikipedia

  • Ricin — (pronEng|ˈraɪ sɨn) is a protein toxin that is extracted from the castor bean ( Ricinus communis ).The U.S. Centers for Disease Control (CDC) gives a possible minimum figure of 500 micrograms (about the size of a grain of salt) Fact|date=May 2008… …   Wikipedia

  • DNA repair — For the journal, see DNA Repair (journal). DNA damage resulting in multiple broken chromosomes DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human… …   Wikipedia

  • Oxoguanine glycosylase — 8 oxoguanine DNA glycosylase PDB rendering based on 1ebm …   Wikipedia

  • Oligonucleotide synthesis — is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure (sequence). The technique is extremely useful in current laboratory practice because it provides a rapid and inexpensive access to custom… …   Wikipedia

  • DNA — For a non technical introduction to the topic, see Introduction to genetics. For other uses, see DNA (disambiguation). The structure of the DNA double helix. The atoms in the structure are colour coded by element and the detailed structure of two …   Wikipedia

  • Mutation — For other uses, see Mutation (disambiguation). Part of the Biology series on Evolution …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”